Light-induced retinal degeneration (LIRD) is commonly used in both rodents and zebrafish
to damage rod and cone photoreceptors. In adult zebrafish, photoreceptor degeneration
triggers Müller glial cells to re-enter the cell cycle and produce transient-amplifying
progenitors. These progenitors continue to proliferate as they migrate to the damaged area,
where they ultimately give rise to new photoreceptors. Currently, there are two widely-used
LIRD paradigms, each of which results in varying degrees of photoreceptor loss and …